Medicinal Potential of Milk: A Meta-Analysis of Bioactive Compounds, Health Benefits, Consumption Patterns, and Policy Implications for Tanzania and Beyond

• Valery Silvery Sonola

  Livestock Training Campus (LITA), Buhuri Campus, P.O. Box 1483, Tanga, Tanzania.

  Author

• Balija Philipo Luyombya

  Livestock Training Agency (LITA), Head Quarter, University of Dodoma, plot no.9, P.O. Box 2866, Dodoma, Tanzania.

  Author

Milk from various animal species is increasingly recognized not only as a nutritional food but also as a functional therapeutic resource due to its rich bioactive compounds. However, disparities exist globally regarding awareness, consumption patterns, and industrial utilization of medicinal milk, particularly in Tanzania and Sub-Saharan Africa. This meta-analysis synthesizes current literature on the medicinal potential of milk, focusing on the types of bioactive compounds, their therapeutic applications, consumption trends, regional awareness, and policy strategies that offer practical lessons for Tanzania. A systematic search was conducted across the PubMed, Scopus, Google Scholar, and ScienceDirect databases, targeting studies published between 2010 and 2024. Data on bioactive compounds, therapeutic efficacy, consumption prevalence, and regional practices were extracted and synthesized. A comparative analysis was performed for Tanzania, East Africa, Sub-Saharan Africa, and global regions. Lactoferrin, immunoglobulins, insulin-like proteins, bioactive peptides, and probiotics are the most studied compounds in cow, goat, camel, sheep, and buffalo milk. Camel milk has demonstrated significant glycemic control effects, with fasting blood glucose reduction ranging from 9% to 18% in diabetic patients. Awareness of milk's medicinal potential remains low in Tanzania (~10%) compared to Kenya (30%), Ethiopia (40%), and Europe (>70%). The industrial extraction of bioactive (e.g., lactoferrin) is limited in Sub-Saharan Africa but well-established in Europe, Asia, and Oceania. Tanzania presents significant untapped potential for integrating medicinal milk into its public health and dairy development strategies. Urgent multi-sectoral efforts focusing on awareness campaigns, research investment, dairy innovation, and policy reforms are essential.

1. Abdelazez, A., H. Abd-elmotaal, and G. Abady, Exploring the potential of camel milk as a functional food: physicochemical characteristics, bioactive components, innovative therapeutic applications, and development opportunities analysis. Food Materials Research, 2024. 4(1).

2. Kober, A.H., Milk and Dairy Foods: Nutrition, Processing and Healthy Aging. 2024: CRC Press

3. Pellegrino, L., et al., Vitamin D fortification of consumption cow’s milk: Health, nutritional and technological aspects. A multidisciplinary lecture of the recent scientific evidence. Molecules, 2021. 26(17): p. 5289.

4. Ianiro, G., et al., To Boost or to Reset: The Role of Lactoferrin in Energy Metabolism. International Journal of Molecular Sciences, 2023. 24(21): p. 15925.

5. Anwar, I., et al., Functional profiling of synthetic camel milk-derived peptides with implication in glucose transport and diabetes. PloS one, 2025. 20(3): p. e0320812.

6. Agrawal, R.P., Budania, S., Sharma, P., Gupta, R., Kochar, D. K., & Sahani, M. S. , Zero prevalence of diabetes in camel milk consuming Raica community of northwest Rajasthan, India. Indian Journal of Medical Research. , 2022. 155(2): p. 295-303.

7. El-Agamy, E.I., Ruppanner, R., Ismail, A., Champagne, C. P., & Assaf, R. , Antibacterial and antiviral activity of camel milk protective proteins. . Journal of Dairy Research., 2009. 76(3): p. 429-435.

8. Chen, L., et al., Health potential of fermented goat dairy products: composition comparison with fermented cow milk, probiotics selection, health benefits and mechanisms. Food & Function, 2023. 14(8): p. 3423-3436.

9. Haenlein, G., Goat milk in human nutrition. Small ruminant research, 2004. 51(2): p. 155-163.

10. Kumar, H., & Patel, R. M. , Nutraceutical potential of goat milk and its products. . International Journal of Livestock Research., 2020. 10(2): p. 1-10.

11. Ghoneim, M., Abdel-Rahman, H., & Elbaz, A. , Functional dairy products: Emerging trends and future perspectives. Journal of Dairy Science, 2022. 105(2): p. 1207-1221.

12. Lopez, C., Madec, M. N., Bouhallab, S., & Jimenez-Flores, R. , Milk fat globule membrane - Biological roles and food applications. Journal of Dairy Science, 2022. 105(1): p. 1-25.

13. Lugamara, C., J. Urassa, and G. Massawe, A review of post-harvest milk losses in Tanzania’s milk sector: Lessons from production to consumption. Tanzania Journal of Agricultural Sciences, 2023. 22(2): p. 1-8.

14. Muthini, D., Mwangi, S., & Wafula, C. , Status of milk consumption and marketing in Tanzania. International Journal of Livestock Policy and Economics., 2023. 5(1): p. 101-114.

15. Mwangi, S., Mdoe, N., & Makoni, N. , Trends and constraints in the Tanzania dairy sector: Implications for policy reforms. Livestock Research for Rural Development., 2023. 35(1): p. 1-12.

16. Ngowi, H.A., Mfinanga, S. G., & Mghamba, J. , The rising burden of non-communicable diseases in Tanzania. Tanzania Journal of Health Research., 2018. 20(1): p. 1-10.

17. Kanis, J.A., Cooper, C., Rizzoli, R., Reginster, J. Y. & Scientific Advisory Board of the European Osteoporosis Foundation. , European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporosis International., 2023. 34(3): p. 405-447.

18. Mteta, A., Makoni, N., & Mdoe, N. , Factors influencing milk consumption in Tanzania: Evidence from Mbeya region. . African Journal of Food Science, 2021. 15(6): p. 206-214.

19. Park, Y., et al., Physico-chemical characteristics of goat and sheep milk. Small ruminant research, 2007. 68(1-2): p. 88-113.

20. Boza, J.J., Barba, F. J., Esteve, M. J., Frigola, A., & Cortes-Cuevas, A., Functional dairy products as a strategy in health promotion: Current knowledge and future perspectives. Critical Reviews in Food Science and Nutrition., 2022. 62(19): p. 5302-5320.

21. Rastogi, T., Ghosh, S., Sahoo, S., & Aggarwal, S., Functional dairy products in India: Health perspectives and future prospects. . Dairy Science & Technology., 2021. 101(4): p. 447-466.

22. Kadara, C., Wanyoike, F., & Irungu, P., Camel milk marketing and utilization in northern Kenya: Current status and future prospects. . Pastoralism: Research, Policy and Practice., 2022. 12(1): p. 1-14.

23. Alharthi, A.S., Alshahrani, M. M., & Alshaikhi, A. M. , Anti-diabetic properties of camel milk: Clinical evidence and therapeutic perspectives. Journal of Ethnopharmacology., 2022. 293 p. 115248.

24. Jomo, S., Muthee, J., & Kirwa, E. , Factors influencing the utilization of camel milk among diabetic patients in Isiolo County, Kenya. . African Journal of Food, Agriculture, Nutrition and Development., 2021. 21(4): p. 18242-18257.

25. Fennell, J., Busayo, O., & Abebe, G. , Camel milk and diabetes management: Evidence from pastoralist communities in Ethiopia. . African Journal of Food Science., 2023. 17(1): p. 18-26.

26. FrieslandCampina., Dairy Innovations: Global Trends in Functional Foods. . FrieslandCampina Annual Dairy Report., 2023.

27. Board., N.Z.D., Dairy Products and Bioactive Innovations. . Annual Dairy Industry Report., 2023.

28. Page, M.J., et al., PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews. bmj, 2021. 372.

29. Higgins JPT, T.J., Chandler J, Cumpston M, Li T, Page MJ, Welch VA. , Cochrane Handbook for Systematic Reviews of Interventions version 6.5 Cochrane, 2024. , 2024.

30. Gough, D., Oliver, S., & Thomas, J. , An Introduction to Systematic Reviews. SAGE Publications., 2017.

31. Aromataris, E. and Z. Munn, JBI manual for evidence synthesis. 2020: Jbi.

32. Egger, M., et al., Bias in meta-analysis detected by a simple, graphical test. bmj, 1997. 315(7109): p. 629-634.

33. Page, M.J., et al., The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. bmj, 2021. 372.

34. Johnson, R.J., Segal, M. S., Sautin, Y., Nakagawa, T., Feig, D. I., Kang, D. H., ... & Sanchez-Lozada, L. G. , Lactoferrin: Friend or foe in health and disease? . Nutrition Reviews., 2021. 79(3): p. 405-418.

35. Kumar, H., & Patel, R. M. , Nutraceutical potential of goat milk and its products. . International Journal of Livestock Research., 2020. 10(2): p. 1-10.

36. Singh, J., Kaur, A., & Sandhu, K. S. , Nutraceutical and therapeutic potential of buffalo milk. . Journal of Food Science and Technology, 60(2), , 2023. 60(2): p. 477-486.

37. Khan, I.T., Nadeem, M., Imran, M., Ullah, R., Ajmal, M., Jaspal, M. H., & Anjum, F. M. , Antioxidant and antimicrobial characteristics of goat milk protein fractions. . Food Chemistry. , 2021. 343 p. 128398.

38. He, J., et al., An insight into the health beneficial of probiotics dairy products: A critical review. Critical Reviews in Food Science and Nutrition, 2023. 63(32): p. 11290-11309.

39. Singh, P. and S.A. Ali, Impact of CRISPR-Cas9-based genome engineering in farm animals. Veterinary Sciences, 2021. 8(7): p. 122.

40. Al-Beltagi, M., Human milk oligosaccharide secretion dynamics during breastfeeding and its antimicrobial role: A systematic review. World Journal of Clinical Pediatrics, 2025. 14(2).

41. Embleton, N.D. and J.E. Berrington, Milk-based bionutrient trials to improve outcomes in preterm infants: Challenges and opportunities. American Journal of Perinatology, 2022. 39(S 01): p. S68-S72.

42. Abdisa, K.B., et al., Metabolic syndrome and biotherapeutic activity of dairy (cow and buffalo) milk proteins and peptides: Fast food-induced obesity perspective—A narrative review. Biomolecules, 2024. 14(4): p. 478.

43. Fischer-Tlustos, A., et al., Insulin, IGF-I, and lactoferrin concentrations and yields and their associations with other components within colostrum, transition, and whole milk of primiparous and multiparous Holstein cattle. JDS communications, 2025. 6(1): p. 137-142.

44. Demir, R., et al., Lactoferrin: Properties and Potential Uses in the Food Industry. International Journal of Molecular Sciences, 2025. 26(4): p. 1404.

45. Board., N.Z.D., Dairy Products and Bioactive Innovations. . Annual Dairy Industry Report., 2023.

46. Park, Y.W., Juárez, M., Ramos, M., & Haenlein, G. F. W., Physico-chemical characteristics of goat and sheep milk. Small Ruminant Research., 2020. . 68(1-2): p. 88-113.

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This is a meta-analysis study based on literature synthesis; therefore, the data are fully available.

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